All 14 games were announced on Wednesday; the challenge will start on Nov. 29.
Iowa head coach Lisa Bluder is no strangers to the Seminoles. During the 2012 challenge, Florida State got the best of Iowa, 83-69, in Tallahassee, Florida.
That was the only meeting between the two teams. Iowa will have home-court advantage this year.
Iowa finished with a 20-14 overall record while making its 10th-straight postseason appearance. The Hawkeyes will have four essential starters, Megan Gustafson, Tania Davis, Kathleen Doyle, and Makenzie Meyer returning for the 2017-18 season.
The Seminoles finished last season 28-7 and advanced to the NCAA Elite Eight before South Carolina eliminated them.
Because the ACC won last year’s challenge with a 9-5 record, the Big Ten will seek some revenge.